In that same year the mansion at Stantonbury was damaged by fire, the extent of which is not known. The Duchess of Marlborough died the following year and bequeathed this manor, along with many other huge estates, to her grandson John Spencer. He became the first Earl Spencer and founded the family which continues to hold its principal seat in Althorp, Northamptonshire.
Earl Spencer never had any occasion to live at Stantonbury but the house may have been used as a residence for stewards of the estate. Certainly this must be the case for Thomas Harrison who built Wolverton House in the 1780s. Harrison's older children were baptised at Stantonbury church in the late 1750 and 1760s, so they were evidently living in the parish and given the almost complete absence of houses for a middle class family of that status one can only assume that they were living in the Wittewronge mansion. Thomas Harrison was the land agent for Earl Spencer and he performed a similar role for the Earl of Uxbridge. In 1773 he took on this same task for the Radcliffe Trust and later established his "seat" at Wolverton. Thomas Harrison, as I have described elsewhere. was an 18th century entrepreneurial spirit who appears to have made a lot of money.
I would speculate that in the 1770s the 100 year old house was in a state of disrepair. The fire of 1743 must have left residual damage and probably the cost of maintenance was no longer worth it. It is quite possible that the Harrisons were the last residents and a decade later, in 1791, the only practical course for Earl Spencer was to demolish the building.